Pycnogenol (150 mg/day) reduced LDL and increased HDL cholesterol in a trial of 25 healthy people after 6 weeks [55]. Enzogenol also may reduce mental fatigue and sleep problems [82]. Side Effects of Pycnogenol. A 2017 review reported on the many benefits of using pine bark extract to reduce the effects of aging on skin. Pycnogenol is a patented extract of the French maritime pine bark (Pinus pinaster). In a smaller study of 58 people, pycnogenol reduced the inflammatory marker CRP [49, 50]. Pycnogenol also treatment improved blood vessel function. In a study of 33 people with severe osteoarthritis, pycnogenol (200 mg/day) reduced inflammatory markers after 3 weeks. For mild high blood pressure: 200 milligrams daily. The antibacterial activity was assessed indicating that the essential oil of pine bark, specifically the proanthocyanidins, were effective against P. aeruginosa, significantly inhibiting its growth. Gotu Kola: Health Benefits, Side Effects, Uses, and More - WebMD Chestnut seed extract did not do as well. In a study of 50 overweight people, a combination product (Pycnogenol, Madeglucyl, and starches called Glucaffect) reduced weight, BMI, blood glucose, and HbA1C after 8 weeks [30]. Its used as a natural supplement for several conditions, including dry skin and ADHD. According to research, Pycnogenol may have a multitude of health benefits, which are likely due to this extracts antioxidant and anti-inflammatory properties. Symptoms include swelling in ankles and legs, discolored skin and, if the skin is broken, the development of leg ulcers. Commonly called arthritis, osteoarthritis is caused when the cartilage on your joints begins to wear down. First and foremost, start eating an anti-inflammatory Local Raw Honey (Bee Pollen) Considering how good it tastes, having some raw honey Apple Cider Vinegar (ACV) You can now find high-quality apple cider vinegar in . Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Due to its anti-inflammatory properties, luteolin is being researched as a potential complementary treatment for multiple . In long-haul flights, Pycnogenol could be an effective prevention for blood clots. The following purported benefits of Pycnogenol are only supported by limited, low-quality clinical studies. More research is needed to see how this supplement affects all of these conditions. It also may help those on blood pressure medications to reduce their dose [32]. In 1535, a French explorer by the name of Jacques Cartier found himself ice-bound on the St. Lawrence River. Note that each number in parentheses [1, 2, 3, etc.] Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. Pycnogenol-treated subjects experienced an improvement in all menopausal symptoms. It also seems to help with cell regeneration and replication. If possible, try to get pine bark extract from a local supplier, such as a health food store. However, some of these other pine bark extracts can have different active compounds, which may affect their biological activity. In a clinical trial of 40 men with erectile dysfunction, 92.5% of the men on this combination regained normal erections after 3 months. However, it can also be used topically. The positive improvements in symptoms were greater among those taking Pycnogenol. In theory, pine bark may lower blood pressure and blood sugar level, and these effects have also been reported in some RCTs. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. Pycnogenol treatment reduced the need for painkillers by 58% versus one percent in the placebo-treated group. Pycnogenol alleviated adverse effects in cancer patients, Pycnogenol improved working memory in older adults, Pycnogenol lowered the use of analgesic drugs in dysmenorrhea (severe menstrual pain), Pycnogenol reduced symptoms in endometriosis comparable to leuprorelin, the standard drug for this condition, Pycnogenol was found to be effective for sun-caused hyperpigmented skin, Pycnogenol reduced the inflammation in lupus patients, Pycnogenol reduced gingival bleeding and plaque formation. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. In the study, the placebo group had higher IgE antibodies to the birch allergen than those who took Pycnogenol during the allergy season [17]. A deficiency can cause issues like anemia, stunted growth, heart problems and neural tube defects. This study adds to a body of research showing the benefits of Pycnogenol for improving circulation and blood flow, strengthening the vascular system and managing cholesterol. Let us discuss them in detail below. Results showed that one month of Pycnogenol led to a significant reduction of hyperactivity with improvement in attention and visual-motor coordination and concentration, as compared to no positive effects in the placebo group. Skin irritation. Its best to check with your doctor about the dosage, based on the symptoms you have and other possible conditions, prior to taking either pine bark extract or Pycnogenol. Pycnogenol lowered leukotrienes as well. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. Natural Factors Pycnogenol 100mg 30 Veggie Caps. (4). Posted on Thursday, August 14, 2014 The majority of this article is information obtained from the book "All About DIM" by Michael A. Zeligs, MD and A. Scott Connelly, MD. Symptoms of menopausal syndrome, also known as climacteric syndrome, include: hot flashes; chills; headache; and depression. Pycnogenol (200 mg/day) may reduce muscle cramps and pain according to a study of 66 healthy people, athletes, and those with venous problems after 4 weeks. However, this was a relatively small study, so larger ones are needed to fully understand pine bark extracts role in these findings. Pycnogenol improved symptoms, circulation, and reduced complications in 156 people with deep vein thrombosis (blot clots in deep leg veins) in a 12-month study. In contrast, almost 20% of the participants on inhalers alone had to increase their dosage. However, it's always a good idea to start with a low dose so you can monitor how your body responds. Vinpocetine is used to increase brain circulation, alertness, cognitive function, concentration, and memory, as well as to lower inflammation and oxidative stress.This article will explore vinpocetine's history, how it works, its potential benefits, and any possible safety issues . Diarrhea. Pycnogenol acts as a sustained-release formulation. Pycnogenol may help reduce symptoms of melasma, a form of hyperpigmentation, possibly because it protects against UV rays. Pycnogenol completely normalized function. There are also several other natural ADHD remedies you can try. Used early on, it may prevent eye damage and blindness from diabetes [34]. Circulation and Jet Lag on Long Flights. It also may help regenerate and maintain vitamin C and E levels while also potentially increasing nitric oxide levels, which may relax and protect blood vessels [1]. 4 Items . Lutein uses and benefits include helping prevent eye conditions like macular degeneration and cataracts, skin disorders and skin cancer, several types of cancer, including colon or breast cancer, type 2 diabetes, and heart disease. In some people lung inflammation is caused by leukotrienes chemicals that are released by the body after a person encounters allergens. Seems like it must be pretty amazing, but lets look closer. Joe Cohen flipped the script on conventional and alternative medicine and it worked. The goal of this study was to evaluate if Pycnogenol could prevent deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) in eight-hour flights in 196 subjects at risk of these conditions. Buying Effective Supplements for ED - Verywell Health Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. 1 Anti-Aging Beverage, An surprisingstudy found that pine bark extract was far better than aspirin at inhibiting smoking-induced clotting, using lower amounts without the bleeding often found when using aspirin. Tell your doctor about any supplements you're taking, even if they're natural. Pine bark extract comes from the inner bark of the Pinus pinaster tree, most commonly found in Europe. As a skin cream, its safe to use for about seven days. Some studies also suggest it can help guard against coronary artery disease and blood clots, per webmd.com. However, in all the above studies insulin levels did not change. Pine bark distill has been studied regarding its relationship to exercise performance, oxidative stress and excitement to torso that has been imposed by exercise. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. In a double-blind, placebo-controlled, randomized, crossover study, 50 patients with erectile dysfunction (ED) were treated with either L-arginine plus Pycnogenol or placebo for a month. Top 10 Health Benefits of Nattokinase - Earth Clinic Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. Pycnogenol in metabolic syndrome and related disorders [Abstract]. You can gradually increase how much you take once you get a better idea of how your body reacts to it. The list goes on a bit further, as the OPCs in thisextract may inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems, which basically means it may be a natural treatment for many serious health conditions, such as stroke and heart disease. Score one for diabetes control and fewer risk factors for the heart. Pycnogenol has four main components that contribute to its benefits for men's health. According to a study of 170 women, low-dose pycnogenol (60 mg/day) may improve menopausal symptoms over 3 months, including night sweats, hot flashes, insomnia and sleep problems [69]. (9), Related:Top 7 Benefits of Green Tea: The No. Studies have shown that the tree bark can help decrease common symptoms including hot flashes, mood swings, irregular periods, and others. So it . Protection from inflammation, immunosuppression and carcinogenesis There havent been enough studies yet to change practice protocols for treating children. Potential benefits of folic acid include a reduced risk of cancer, improved cognitive function, stronger bones, enhanced heart health, better pregnancy outcomes and reduced symptoms of restless legs syndrome. ", Mayo Clinic: High blood pressure (hypertension)., Panminerva Medica: "Pycnogenol improvements in asthma management. Pycnogenol may stimulate the immune system. A sitz bath, which involves sitting in warm water for 10 minutes, twice daily, is helpful to patients with anal itching, aching or burning and is known as one of the best ways to get rid of hemorrhoids fast. , Improves Symptoms Associated With Menopause, A number of women experience physical discomfort due to symptoms of menopause. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Researchers suggest this effect may be due to reduced dopamine and adrenaline levels and increased glutathione levels. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body . It also reduced the size of scars. Pycnogenol: Uses and Risks - WebMD Take Helpful Supplements. There are several causes for erectile dysfunction, such as neurological and psychological issues. Pine Bark Extract Health Benefits, Nutrition and How to Use - Dr. Axe This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk . This bark extract has been around for about 450 years. A combination product with Pycnogenol (Lady Prelox) improved sexual function in a clinical trial of 83 healthy postmenopausal women after 8 weeks. Pycnogenol may have benefits for heart and artery health. Rating: 100%. Talk to your own doctor about Pycnogenol if youre interested in using it for your own health. Pycnogenol significantly improved the heavy feeling as well as the swelling. According to researchers, it may help prevent the rise in free radicals typically seen after exercise, which could cause muscle fatigue and damage [9]. It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. However, a study of 24 adults with ADHD found that pycnogenol did not improve ADHD symptoms better than placebo. Two studies illustrate the possibilities: One was a randomized, double-blind, placebo-controlled, crossover study in which 26 asthmatic patients were given either a maximum of 200 mg a day of Pycnogenol or placebo for the first period of four weeks and then crossed over to the alternate treatment for the next four weeks. after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. Diindolylmethane, or DIM for short, is a plant indolea plant compound with health-promoting properties. Pine Bark Extract Health Benefits, Nutrition and How to Use - Dr. Axe Another clinical trial of 76 people with allergic asthma also suggests that Pycnogenol may reduce IgE antibodies and asthma symptoms [18, 16]. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. What Are These Tiny Red Spots on My Skin (Petechiae)? (2004). Top Anti-Aging Properties Of Pycnogenol - Life Extension While much of this is positive, it will be a while before doctors routinely recommend this dietary supplement for these conditions. Rare cases of liver disease. Pycnogenol: Health Benefits, Uses, Doses, Safety Information - WebMD Taking pine bark extract supports healthy blood pressure. Learn about this tree-based pill and how it might be able to help you. (2006). Here are 12 benefits of ginkgo biloba. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. . 2005 - 2023 WebMD LLC. DOI: Dvorkov M, et al. What Is Pycnogenol, and What's It Used For? - Wonder Labs But two months ago, erectile dysfunction health food with the help of the Divine Tool Alliance, the price of all materials related to the puppet mechanism was raised by 20 erectile dysfunction health food 30 , and the price of selling the puppet was reduced by 10. If youre wondering how to get an even skin tone, there are plenty of remedies that can help. You can learn more about how we ensure our content is accurate and current by reading our. 40 years of research has been dedicated to establishing the safety of Pycnogenol and its benefits for human health. Benefits of Pycnogenol - Healthy Directions Chanca Piedra: Benefits, Dosage, Side Effects, and More - Healthline Grapes: Health Benefits, Nutrition, Recipes and Risks - Dr. Axe We believe that the most accurate information is found directly in the scientific source. Pycnogenol Benefits, Dosage & Side Effects - Ayur Times Clinical research suggests that Pycnogenol is possibly effective for improving athletic performance. Healthline Media does not provide medical advice, diagnosis, or treatment. (2017). This can cause pain, especially in areas of the body that are used repeatedly, like your hands, fingers, and knees. Plus, it reduced total and LDL (bad) cholesterol. Moreover, Pycnogenol treatment reduced the use of painkillers. Pycnogenol seems well-tolerated for use in adults for up to 6 months. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. It may cause side effects such as: Dizziness. However, its always a good idea to start with a low dose so you can monitor how your body responds. One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. The active ingredients in pycnogenol can also be extracted from other sources, including peanut skin, grape seed, and witch hazel bark. A combination supplement (pycnogenol with collagen, coenzyme Q10, and other ingredients) reduced skin aging, elasticity, hydration, and tonicity in a study of 30 women [65]. You can find out your systolic blood pressure by looking at the top number of a blood pressure test. A study of 30 women found that Pycnogenol (75 mg/day) may reduce the skin area affected by melasma as well as lower symptoms of fatigue, constipation, body pain, and anxiety [62]. A 2015 review indicates that pine bark extract can be used to treat metabolic syndrome and related disorders such as obesity, diabetes, and high blood pressure. (11, 12), While both eliminate pain, the pine bark extract is a far better choice. Pycnogenol is known under different names in some countries, such as Oligopin, and Flavangenol in Japan [4, 5]. Traditionally, people might drink a brew made from pine bark -- rich in pycnogenol -- as a treatment. We avoid using tertiary references. (10), A 15-year Dutch study was published stating that 27,939 healthy female health professionals were given aspirin or a placebo for a period of time. A randomized, double-blind, placebo-controlled study of 60 patients aged six to 18 years old, was conducted over three months during which patients were randomly assigned to receive either Pycnogenol or placebo. The same ingredient can be found in grapeseed oil, the skin of peanuts and witch hazel bark. chronic anal fissure may take more than 6 weeks to heal. Eliminate blood clots. She loves communicating science and empowering people to achieve their optimal health. 12 Benefits of Pycnogenol (Pine Bark Extract) According to Studies This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. In the Pycnogenol-treated group, blood sugar levels were significantly lowered as compared to those not on Pycnogenol. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25].